Still Experiencing Depression Symptoms Despite Treatment?

Take a short questionnaire to see if you may qualify for a research study of an investigational depression medication.

See If You May Qualify
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See If You May Qualify

About Major Depressive Disorder

Major depressive disorder (MDD), often called depression, is a common mental health condition that can affect many aspects of daily life, including mood, energy, sleep, relationships, and overall well-being.

When a person experiences depression symptoms nearly every day for most of the day over a period of at least 2 weeks, this is called a depressive episode. Depressive episodes can last anywhere from 3 to 12 months if untreated.

While depression symptoms can vary from person to person, these symptoms often include:

Mood Changes

Persistent sadness, anxiety, feelings of worthlessness or hopelessness. Some people may also experience irritability along with sadness.

Loss of Interest

A lack of pleasure in hobbies, sports, social activities, relationships, or other activities that were previously enjoyed.

Physical Exhaustion

Constant fatigue, lack of energy, or feeling that even small tasks require overwhelming effort.

Sleep Disruptions

Insomnia, waking up too early, or hypersomnia (sleeping too much).

Appetite or Weight Changes

Significant unplanned weight loss or gain, or dramatic change in interest in food.

Cognitive Difficulties

Brain fog, poor concentration, memory issues, or trouble making simple decisions.

Emotional Difficulties

Hopelessness, worthlessness, or excessive guilt.

Behavioral Shifts

Social withdrawal, increased use of drugs or alcohol.

While treatment options are available, some adults continue to experience symptoms despite taking antidepressant treatment. This can be called an inadequate response.

Inadequate responses can be divided into the following two categories:

Partial response

If a person takes at least 2 different antidepressants with 25% to 50% or less symptom improvement, this is called a partial response.

Difficult-to-treat depression

When someone has taken at least 2 different antidepressants with less than 25% improvement in symptoms during a depressive episode, this is defined as “difficult-to-treat depression.”

See If You May Qualify

About This Study

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This clinical research study is evaluating an investigational medication in adults ages 18 to 65 with major depressive disorder.

To enroll in this study, participants must have had an inadequate response (either partial response or difficult-to-treat depression) to at least two different antidepressant medications, with at least one inadequate response occurring in your current depressive episode.

Study participation involves study visits and ongoing health monitoring by the study team. All study-related care is provided at no cost, and compensation may be available for time and travel.

If you are interested in learning more, the first step is a short questionnaire. Your answers will help determine whether this study may be a good fit for you and if there is a study clinic near you.

If you complete the brief questionnaire and prequalify based on your answers, you will be provided with instructions for the next steps in the pre-screening process.

Start the Questionnaire
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See if this study is right for you

How it works:

Answer a brief questionnaire

Find out if you may qualify

If you pre-qualify based on your responses, you will be provided with instructions for the next steps in the pre-screening process.

Pre-Qualifying Questionnaire

To see if you qualify for this research study, please complete this Pre-Qualifying Questionnaire.

Next Steps

If you decide to move forward, click on “Begin” to complete a brief pre-qualification questionnaire for the study.

If you pre-qualify based on your responses, you will be provided with instructions for the next steps in the pre-screening process.

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Participating Study Centers

Inland Psychiatric Medical Group

Viviana Tapia

(909) 488-9116

5475 Walnut Avenue
2nd Floor
Chino, California 91710 (map)

Behavioral Research Specialists

Natalie Akins

(888) 255-5798

230 N. Maryland Avenue
Suite 207
Glendale, California 91206 (map)

Kadima Neuropsychiatry Institute

Auriana Irannejad

(858) 775-2053 ext. 107

3252 Holiday Court
Suite 112
La Jolla, California 92037 (map)

ATP Clinical Research

Caraline Lunter

(949) 354-5353

302 West LaVeta Avenue
Suite 201
Orange, California 92866 (map)

Mountain View Clinical Research

Paul Avila

(720) 941-9363 ext. 05

3955 E. Exposition Avenue
Suite 100
Denver, Colorado 80209 (map)

New Access Research & Medical Services, Inc.

Sandra Matos

(786) 459-0756

2665 Cleveland Avenue
Suite 201
Ft. Myers, Florida 33901 (map)

The Medici Medical Research

Yesenia Kuan, MD

(786) 408-4636

3801 Hollywood Boulevard
Suite 200
Hollywood, Florida 33021 (map)

Clinical Neuroscience Solutions

Letitia Griffin

(407) 425-5100

618 E. South Street
Suite 100
Orlando, Florida 32801 (map)

IPTB Clinical Research

Alyssa Leanza

(813) 772-0355

3810 W. Neptune Street
Suite B3
Tampa, Florida 33629 (map)

Neuroscience Research Institute

Conor Burke

(561) 578-8573

222 Picadilly Street
West Palm Beach, Florida 33407 (map)

Vitalix Clinical

John Henry Sturdy

(508) 723-3730

554 Main Street
Worcester, Massachusetts 01608 (map)

Precise Research Centers

Karen Richardson

(601) 420-5812

3531 Lakeland Drive
Suite 1060
Flowood, Mississippi 39232 (map)

Midwest Research Group

Lindsay Van Winkle

(636) 946-8032 ext. 5

4801 Weldon Spring Parkway
Suite 300
St. Charles, Missouri 63304 (map)

Alivation Research

Elizabeth Ludwig

(402) 817-2236

8550 Cuthills Circle
Lincoln, Nebraska 68526 (map)

Redbird Research

Pam Pioquinto

(702) 577-2000

6817 S. Eastern Avenue
Suite 102
Las Vegas, Nevada 89134 (map)

Integrative Clinical Trials

Olha Bilobrova

(718) 444-7774 ext. 121

2409 Ocean Avenue
Unit 1F
Brooklyn, New York 11229 (map)

Magnolia Clinical Research

Lilian Cervera

(984) 345-3010

1505 SW Cary Parkway
Suite 210
Cary, North Carolina 27511 (map)

Neuro-Behavioral Clinical Research

Nate Fontes

(330) 493-1118

5080 Aultman Avenue NW
North Canton, Ohio 44720 (map)

Baylor College of Medicine (Ben Taub Hospital)

Abraham Sohaib Tauheed

(713) 873-5145

1502 Taub Loop
3rd Floor, Neuropsychiatric Center
Houston, Texas 77030 (map)

Olympus Clinical Research

Tiffany Lowe

(346) 397-4457 ext. 1053

539 S. Mason Road
Katy, Texas 77450 (map)

Family Psychiatry of The Woodlands

Sue Goldsby, RN, PMH-BC

(832) 616-2675

8701 New Trails Drive
Suite 150
The Woodlands, Texas 77381 (map)

Aura Wellness

Jessica Andrus

(801) 872-3424

1524 South 1100 East
Suite B
Salt Lake City, Utah 84105 (map)

Frequently Asked Questions (FAQs)

Doctors and scientists are constantly discovering new medications and devices that may help prevent, detect, diagnose, control, and treat illnesses. A research study or clinical trial is a scientific study that tests these new discoveries for safety and how well they work. Research studies depend upon the participation of volunteers.
A placebo is an inactive study treatment designed to look like the investigational medication. Researchers use placebos to compare to study medications in order to better understand the effects of the investigational medications.
Participation in a research study is completely voluntary. In all research studies, qualified potential participants are first informed about the research study in detail. After receiving this information, all participants must give their consent in writing to proceed. Some research studies involve more tests and doctor visits than the participant would normally have for an illness or condition.
This research study may yield new information that could benefit people in the future by helping to answer questions about the investigational drug. While participants may not receive direct medical benefit from participating in this study, they may be compensated for their time and travel.
Before participating in a research study, volunteers must meet specific requirements. These requirements are based on various factors, such as age, medical history, current health status, current medications, and allergies. The circumstances that allow a person to participate are called Inclusion Criteria (requirements to join), and those that prevent participation are called Exclusion Criteria (reasons you may not be able to join). These requirements are used to ensure the accuracy of the study as well as the safety of all participants. We will not know whether you satisfy all study requirements until we speak with you and, if appropriate, complete a screening assessment at our facilities.
There is no cost to participate, receive the investigational drug, visit the study center, or undergo study-related procedures, tests, and exams. Participants who meet study requirements may be compensated for study-related time and travel.

See If This Study May Be a Fit

Start the Questionnaire